Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described.
Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity.
Conclusion: Combined analytical, structure-function, and mode...
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Bibliographic Details
| Main Authors: |
Abdul-Ridha, Alaa,
Lane, J. Robert,
Mistry, Shailesh N.,
Lopez, Laura,
Sexton, Patrick M.,
Scammells, Peter J.,
Christopoulos, Arthur,
Canals, Meritxell |
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| Format: | Article
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| Published: |
American Society for Biochemistry and Molecular Biology
2014
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| Online Access: | https://eprints.nottingham.ac.uk/30312/
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