Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time

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Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time

Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrPSc phenotypes were present: G338...

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Bibliographic Details
Main Authors:	Maddison, Ben C., Spiropoulos, John, Vickery, Christopher M., Lockey, Ricahrd, Owen, Jonathan P., Bishop, Keith, Baker, Claire A., Gough, Kevin C.
Format:	Article
Published:	BioMed Central 2015
Online Access:	https://eprints.nottingham.ac.uk/30242/

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