Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time
Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrPSc phenotypes were present: G338...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
BioMed Central
2015
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| Online Access: | https://eprints.nottingham.ac.uk/30242/ |