Circulation of prions within dust on a scrapie affected farm
Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplifi...
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| Format: | Article |
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BioMed Central
2015
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| Online Access: | https://eprints.nottingham.ac.uk/30238/ |
| _version_ | 1848793948141649920 |
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| author | Gough, Kevin C. Baker, Claire A. Simmons, Hugh A. Hawkins, Steve A. Maddison, Ben C. |
| author_facet | Gough, Kevin C. Baker, Claire A. Simmons, Hugh A. Hawkins, Steve A. Maddison, Ben C. |
| author_sort | Gough, Kevin C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises. |
| first_indexed | 2025-11-14T19:08:24Z |
| format | Article |
| id | nottingham-30238 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:08:24Z |
| publishDate | 2015 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-302382020-05-04T17:06:37Z https://eprints.nottingham.ac.uk/30238/ Circulation of prions within dust on a scrapie affected farm Gough, Kevin C. Baker, Claire A. Simmons, Hugh A. Hawkins, Steve A. Maddison, Ben C. Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises. BioMed Central 2015-04-16 Article PeerReviewed Gough, Kevin C., Baker, Claire A., Simmons, Hugh A., Hawkins, Steve A. and Maddison, Ben C. (2015) Circulation of prions within dust on a scrapie affected farm. Veterinary Research, 46 . p. 40. ISSN 0928-4249 http://www.veterinaryresearch.org/content/46/1/40 doi:10.1186/s13567-015-0176-1 doi:10.1186/s13567-015-0176-1 |
| spellingShingle | Gough, Kevin C. Baker, Claire A. Simmons, Hugh A. Hawkins, Steve A. Maddison, Ben C. Circulation of prions within dust on a scrapie affected farm |
| title | Circulation of prions within dust on a scrapie affected farm |
| title_full | Circulation of prions within dust on a scrapie affected farm |
| title_fullStr | Circulation of prions within dust on a scrapie affected farm |
| title_full_unstemmed | Circulation of prions within dust on a scrapie affected farm |
| title_short | Circulation of prions within dust on a scrapie affected farm |
| title_sort | circulation of prions within dust on a scrapie affected farm |
| url | https://eprints.nottingham.ac.uk/30238/ https://eprints.nottingham.ac.uk/30238/ https://eprints.nottingham.ac.uk/30238/ |