Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome

Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome

Background: Phage-encoded serine integrases, such as φC31 integrase, are widely used for genome engineering. Fifteen such integrases have been described but their utility for genome engineering has not been compared in uniform assays. Results: We have compared fifteen serine integrases for their u...

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Bibliographic Details
Main Authors: Xu, Zhengyao, Thomas, Louise, Davies, Ben, Chalmers, Ronald, Smith, Maggie, Brown, William
Format: Article
Published: BioMec Central 2013
Online Access:https://eprints.nottingham.ac.uk/2976/

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