Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms
Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of the repair enzyme protein L-isoaspartyl O-methyltra...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Public Library of Science
2013
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| Online Access: | https://eprints.nottingham.ac.uk/2971/ |