Biochemical analysis of the nuclease module of the human Ccr4-Not deadenylase complex

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Biochemical analysis of the nuclease module of the human Ccr4-Not deadenylase complex

In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key step in mRNA degradation. The Ccr4-Not complex is well-characterised as a major deadenylase enzyme involved in mRNA deadenylation. The complex contains two catalytic subunits: Ccr4 and...

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Bibliographic Details
Main Author:	Maryati, Maryati
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2015
Online Access:	https://eprints.nottingham.ac.uk/29229/

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