Biochemical analysis of the nuclease module of the human Ccr4-Not deadenylase complex
In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key step in mRNA degradation. The Ccr4-Not complex is well-characterised as a major deadenylase enzyme involved in mRNA deadenylation. The complex contains two catalytic subunits: Ccr4 and...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2015
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| Online Access: | https://eprints.nottingham.ac.uk/29229/ |