DEF6, a novel substrate for the tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies

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DEF6, a novel substrate for the tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies

Localization of DEF6 (SLAT/IBP), a Rho-family guanine nucleotide exchange factor, to the center of the immune synapse is dependent upon ITK, a Tec-family kinase that regulates the spatiotemporal organization of components of T cell signaling pathways and Cdc42-dependent actin polymerization. Here we...

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Bibliographic Details
Main Authors:	Hey, Fiona, Czyzewicz, Nathan, Jones, Peter, Sablitzky, Fred
Format:	Article
Published:	American Society for Biochemistry and Molecular Biology
Subjects:	Cell Biology Guanine Nucleotide Exchange Factor (GEF) P-body Signal Transduction T-cell Receptor
Online Access:	https://eprints.nottingham.ac.uk/2918/

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