DEF6, a novel substrate for the tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies
Localization of DEF6 (SLAT/IBP), a Rho-family guanine nucleotide exchange factor, to the center of the immune synapse is dependent upon ITK, a Tec-family kinase that regulates the spatiotemporal organization of components of T cell signaling pathways and Cdc42-dependent actin polymerization. Here we...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
American Society for Biochemistry and Molecular Biology
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/2918/ |