High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines

High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines

Myotonic dystrophy (DM) is a multi-system neuromuscular disorder for which there is no treatment. We have developed a medium throughput phenotypic assay, based on the identification of nuclear foci in DM patient cell lines using in situ hybridization and high-content imaging to screen for potentiall...

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Bibliographic Details
Main Authors: Ketley, Ami, Chen, Catherine Z., Li, Xin, Arya, Sukrat, Robinson, Thelma E., Granados-Riveron, Javier T., Udosen, Inyang, Morris, Glenn E., Holt, Ian, Furling, Dennis, Chaouch, Soraya, Haworth, Ben, Southall, Noel, Shinn, Paul, Zheng, Wei, Austin, Christopher P., Hayes, Christopher J., Brook, J. David
Format: Article
Published: Oxford University Press 2014
Online Access:https://eprints.nottingham.ac.uk/2905/

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https://eprints.nottingham.ac.uk/2905/

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