Protective role of female gender in programmed accelerated renal aging in the rat
The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. To address this we used an established model of developmentally prog...
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| Format: | Article |
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Wiley Open Access
2015
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| Online Access: | https://eprints.nottingham.ac.uk/28727/ |
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| author | Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A. Langley-Evans, Simon C. McMullen, Sarah |
| author_facet | Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A. Langley-Evans, Simon C. McMullen, Sarah |
| author_sort | Pijacka, Wioletta |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. To address this we used an established model of developmentally programmed accelerated renal aging in the rat, superimposed by ovariectomy to assess interactions between ovarian hormones and the aging process. Under our experimental conditions, we found that kidney function worsens with age, that is GFR reduces over 18 month analyzed time-course and this was worsened by fetal exposure to maternal low-protein diet and absence of estrogen. Reduction in GFR was followed by increases in albuminuria, proteinuria, inflammatory markers, and tissue carbonyls, all suggesting inflammatory response and oxidative stress. This was associated with changes in AGTR2 expression which was greater at 18 months of age compared to earlier time points, but in MLP offspring only. Our studies show an influence of ovarian hormones on programmed accelerated renal aging and the AGTR2 across the lifespan. The main findings are that ovariectomy is a risk factor for increased aging-related renal injury and that this and oxidative damage might be related to changes in AGTR2 expression. |
| first_indexed | 2025-11-14T19:03:23Z |
| format | Article |
| id | nottingham-28727 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:03:23Z |
| publishDate | 2015 |
| publisher | Wiley Open Access |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-287272020-05-04T17:06:13Z https://eprints.nottingham.ac.uk/28727/ Protective role of female gender in programmed accelerated renal aging in the rat Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A. Langley-Evans, Simon C. McMullen, Sarah The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. To address this we used an established model of developmentally programmed accelerated renal aging in the rat, superimposed by ovariectomy to assess interactions between ovarian hormones and the aging process. Under our experimental conditions, we found that kidney function worsens with age, that is GFR reduces over 18 month analyzed time-course and this was worsened by fetal exposure to maternal low-protein diet and absence of estrogen. Reduction in GFR was followed by increases in albuminuria, proteinuria, inflammatory markers, and tissue carbonyls, all suggesting inflammatory response and oxidative stress. This was associated with changes in AGTR2 expression which was greater at 18 months of age compared to earlier time points, but in MLP offspring only. Our studies show an influence of ovarian hormones on programmed accelerated renal aging and the AGTR2 across the lifespan. The main findings are that ovariectomy is a risk factor for increased aging-related renal injury and that this and oxidative damage might be related to changes in AGTR2 expression. Wiley Open Access 2015-04-22 Article PeerReviewed Pijacka, Wioletta, Clifford, Bethan, Tilburgs, Chantal, Joles, Jaap A., Langley-Evans, Simon C. and McMullen, Sarah (2015) Protective role of female gender in programmed accelerated renal aging in the rat. Physiological Reports, 3 (4). e12342. ISSN 2051-817X http://physreports.physiology.org/content/3/4/e12342 doi:10.14814/phy2.12342 doi:10.14814/phy2.12342 |
| spellingShingle | Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A. Langley-Evans, Simon C. McMullen, Sarah Protective role of female gender in programmed accelerated renal aging in the rat |
| title | Protective role of female gender in programmed accelerated renal aging in the rat |
| title_full | Protective role of female gender in programmed accelerated renal aging in the rat |
| title_fullStr | Protective role of female gender in programmed accelerated renal aging in the rat |
| title_full_unstemmed | Protective role of female gender in programmed accelerated renal aging in the rat |
| title_short | Protective role of female gender in programmed accelerated renal aging in the rat |
| title_sort | protective role of female gender in programmed accelerated renal aging in the rat |
| url | https://eprints.nottingham.ac.uk/28727/ https://eprints.nottingham.ac.uk/28727/ https://eprints.nottingham.ac.uk/28727/ |