Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

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Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DP...

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Bibliographic Details
Main Authors:	Schwehm, Carolin, Li, Jin, Song, Hongmei, Hu, Xiao, Kellam, Barrie, Stocks, Michael
Format:	Article
Published:	American Chemical Society 2015
Subjects:	Diabetes Scaffold Crystal Structure Dipeptyl Peptidase VI (DPP-4) Inhibitor 1 2 4-Triazole
Online Access:	https://eprints.nottingham.ac.uk/28517/

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