Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DP...

Full description

Bibliographic Details
Main Authors: Schwehm, Carolin, Li, Jin, Song, Hongmei, Hu, Xiao, Kellam, Barrie, Stocks, Michael
Format: Article
Published: American Chemical Society 2015
Subjects:
Online Access:https://eprints.nottingham.ac.uk/28517/