Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold
A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DP...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
American Chemical Society
2015
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/28517/ |
| _version_ | 1848793587620249600 |
|---|---|
| author | Schwehm, Carolin Li, Jin Song, Hongmei Hu, Xiao Kellam, Barrie Stocks, Michael |
| author_facet | Schwehm, Carolin Li, Jin Song, Hongmei Hu, Xiao Kellam, Barrie Stocks, Michael |
| author_sort | Schwehm, Carolin |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown. |
| first_indexed | 2025-11-14T19:02:40Z |
| format | Article |
| id | nottingham-28517 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:02:40Z |
| publishDate | 2015 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-285172020-05-04T17:01:06Z https://eprints.nottingham.ac.uk/28517/ Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold Schwehm, Carolin Li, Jin Song, Hongmei Hu, Xiao Kellam, Barrie Stocks, Michael A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown. American Chemical Society 2015-01-13 Article PeerReviewed Schwehm, Carolin, Li, Jin, Song, Hongmei, Hu, Xiao, Kellam, Barrie and Stocks, Michael (2015) Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold. ACS Medicinal Chemistry Letters, 6 (3). pp. 324-328. ISSN 1948-5875 Diabetes Scaffold Crystal Structure Dipeptyl Peptidase VI (DPP-4) Inhibitor 1 2 4-Triazole http://pubs.acs.org/doi/abs/10.1021/ml500503n doi:10.1021/ml500503n doi:10.1021/ml500503n |
| spellingShingle | Diabetes Scaffold Crystal Structure Dipeptyl Peptidase VI (DPP-4) Inhibitor 1 2 4-Triazole Schwehm, Carolin Li, Jin Song, Hongmei Hu, Xiao Kellam, Barrie Stocks, Michael Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold |
| title | Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold |
| title_full | Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold |
| title_fullStr | Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold |
| title_full_unstemmed | Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold |
| title_short | Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold |
| title_sort | synthesis of new dpp-4 inhibitors based on a novel tricyclic scaffold |
| topic | Diabetes Scaffold Crystal Structure Dipeptyl Peptidase VI (DPP-4) Inhibitor 1 2 4-Triazole |
| url | https://eprints.nottingham.ac.uk/28517/ https://eprints.nottingham.ac.uk/28517/ https://eprints.nottingham.ac.uk/28517/ |