Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction

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Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction

Protein interactions are increasingly appreciated as targets in small-molecule drug discovery. The interaction between the adapter protein S100A10 and its binding partner annexin A2 is a potentially important drug target. To obtain small-molecule starting points for inhibitors of this interaction, a...

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Bibliographic Details
Main Authors:	Reddy, Tummala R.K., Li, Chan, Fischer, Peter M., Dekker, Lodewijk V.
Format:	Article
Published:	Wiley-VCH Verlag 2012
Online Access:	https://eprints.nottingham.ac.uk/2835/

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