Drug-targetting of duplex and quadruplex DNA
This thesis investigates structural and dynamic properties of drug recognition mechanisms to duplex and quadruplex DNA using primarily high field NMR techniques and molecular dynamics simulations. The mechanism of co-operative binding of Hoechst 33258 to the DNA minor groove of duplexes that contai...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2002
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| Online Access: | https://eprints.nottingham.ac.uk/27683/ |