Alkaloid inspired spirocyclic oxindoles from 1,3-dipolar cycloaddition of pyridinium ylides
Cycloaddition reactions between pyridinium ylides and 3-alkenyl oxindoles that proceed in high yield and with very good regio- and diastereoselectivity are reported. The resulting cycloadducts have the same stereochemistry of biologically active oxindole alkaloids, such as strychnofoline.
Bibliographic Details
| Main Authors: |
Day, Jonathan,
Uroos, Maliha,
Castledine, Richard A.,
Lewis, William,
McKeever-Abbas, Ben,
Dowden, James |
|---|
| Format: | Article
|
|---|
| Published: |
Royal Society of Chemistry
2013
|
|---|
| Online Access: | https://eprints.nottingham.ac.uk/2738/
|
|---|