Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health
Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pa...
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| Format: | Article |
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MDPI
2012
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| Online Access: | https://eprints.nottingham.ac.uk/2702/ |
| _version_ | 1848790853879857152 |
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| author | Mobasheri, Ali Henrotin, Yves Biesalski, Hans-Konrad Shakibaei, Mehdi |
| author_facet | Mobasheri, Ali Henrotin, Yves Biesalski, Hans-Konrad Shakibaei, Mehdi |
| author_sort | Mobasheri, Ali |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods. |
| first_indexed | 2025-11-14T18:19:13Z |
| format | Article |
| id | nottingham-2702 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:13Z |
| publishDate | 2012 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-27022020-05-04T20:21:43Z https://eprints.nottingham.ac.uk/2702/ Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health Mobasheri, Ali Henrotin, Yves Biesalski, Hans-Konrad Shakibaei, Mehdi Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods. MDPI 2012-04 Article PeerReviewed Mobasheri, Ali, Henrotin, Yves, Biesalski, Hans-Konrad and Shakibaei, Mehdi (2012) Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. International Journal of Molecular Sciences, 13 (4). pp. 4202-4232. ISSN 1422-0067 http://www.mdpi.com/1422-0067/13/4/4202 doi:10.3390/ijms13044202 doi:10.3390/ijms13044202 |
| spellingShingle | Mobasheri, Ali Henrotin, Yves Biesalski, Hans-Konrad Shakibaei, Mehdi Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
| title | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
| title_full | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
| title_fullStr | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
| title_full_unstemmed | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
| title_short | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
| title_sort | scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
| url | https://eprints.nottingham.ac.uk/2702/ https://eprints.nottingham.ac.uk/2702/ https://eprints.nottingham.ac.uk/2702/ |