Genetic basis for personalized medicine in asthma
There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; β2-adrenergic receptor agonists, corticosteroids and leukotriene m...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Published: |
Expert Reviews
2012
|
| Online Access: | https://eprints.nottingham.ac.uk/2688/ |
| _version_ | 1848790850111275008 |
|---|---|
| author | Portelli, Michael A. Sayers, Ian |
| author_facet | Portelli, Michael A. Sayers, Ian |
| author_sort | Portelli, Michael A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; β2-adrenergic receptor agonists, corticosteroids and leukotriene modifiers. Pharmacogenetics holds great promise to maximise clinical outcomes and minimize adverse effects. Asthma is heterogeneous with respect to clinical presentation and inflammatory mechanisms underlying the disease, which is likely to contribute to variable results in clinical trials targeting specific inflammatory mediators. Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets. In this article, we review and update the pharmacogenetics of current asthma therapies and discuss the genetics underlying selected Phase II and future targets. |
| first_indexed | 2025-11-14T18:19:10Z |
| format | Article |
| id | nottingham-2688 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:10Z |
| publishDate | 2012 |
| publisher | Expert Reviews |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-26882020-05-04T20:21:43Z https://eprints.nottingham.ac.uk/2688/ Genetic basis for personalized medicine in asthma Portelli, Michael A. Sayers, Ian There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; β2-adrenergic receptor agonists, corticosteroids and leukotriene modifiers. Pharmacogenetics holds great promise to maximise clinical outcomes and minimize adverse effects. Asthma is heterogeneous with respect to clinical presentation and inflammatory mechanisms underlying the disease, which is likely to contribute to variable results in clinical trials targeting specific inflammatory mediators. Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets. In this article, we review and update the pharmacogenetics of current asthma therapies and discuss the genetics underlying selected Phase II and future targets. Expert Reviews 2012-04 Article PeerReviewed Portelli, Michael A. and Sayers, Ian (2012) Genetic basis for personalized medicine in asthma. Expert Review of Respiratory Medicine, 6 (2). pp. 223-236. ISSN 1747-6348 http://www.expert-reviews.com/doi/abs/10.1586/ers.12.9 doi:10.1586/ers.12.9 doi:10.1586/ers.12.9 |
| spellingShingle | Portelli, Michael A. Sayers, Ian Genetic basis for personalized medicine in asthma |
| title | Genetic basis for personalized medicine in asthma |
| title_full | Genetic basis for personalized medicine in asthma |
| title_fullStr | Genetic basis for personalized medicine in asthma |
| title_full_unstemmed | Genetic basis for personalized medicine in asthma |
| title_short | Genetic basis for personalized medicine in asthma |
| title_sort | genetic basis for personalized medicine in asthma |
| url | https://eprints.nottingham.ac.uk/2688/ https://eprints.nottingham.ac.uk/2688/ https://eprints.nottingham.ac.uk/2688/ |