WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma

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WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma

Background: Medulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood. Methods: We have developed a model of WNT/β-caten...

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Bibliographic Details
Main Authors:	Rogers, H.A., Sousa, S., Salto, C., Arenas, E., Coyle, B., Grundy, Richard G.
Format:	Article
Published:	Cancer Research UK 2012
Online Access:	https://eprints.nottingham.ac.uk/2542/

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