WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma
Background: Medulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood. Methods: We have developed a model of WNT/β-caten...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Cancer Research UK
2012
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| Online Access: | https://eprints.nottingham.ac.uk/2542/ |