Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis
Background Previous experiments have shown that the reduced gravity aboard the International Space Station (ISS) causes important alterations in Drosophila gene expression. These changes were shown to be intimately linked to environmental space-flight related constraints. Results Here, we u...
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| Format: | Article |
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BioMed Central
2013
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| Online Access: | https://eprints.nottingham.ac.uk/2483/ |
| _version_ | 1848790796884508672 |
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| author | Herranz, Raul Larkin, Oliver J. Hill, Richard J.A. Lopez-Vidriero, Irene van Loon, Jack J.W.A. Medina, F. Javier |
| author_facet | Herranz, Raul Larkin, Oliver J. Hill, Richard J.A. Lopez-Vidriero, Irene van Loon, Jack J.W.A. Medina, F. Javier |
| author_sort | Herranz, Raul |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Previous experiments have shown that the reduced gravity aboard the International Space Station (ISS) causes important alterations in Drosophila gene expression. These changes were shown to be intimately linked to environmental space-flight related constraints.
Results
Here, we use an array of different techniques for ground-based simulation of microgravity effects to assess the effect of suboptimal environmental conditions on the gene expression of Drosophila in reduced gravity. A global and integrative analysis, using “gene expression dynamics inspector” (GEDI) self-organizing maps, reveals different degrees in the responses of the transcriptome when using different environmental conditions or microgravity/hypergravity simulation devices. Although the genes that are affected are different in each simulation technique, we find that the same gene ontology groups, including at least one large multigene family related with behavior, stress response or organogenesis, are over represented in each case.
Conclusions
These results suggest that the transcriptome as a whole can be finely tuned to gravity force. In optimum environmental conditions, the alteration of gravity has only mild effects on gene expression but when environmental conditions are far from optimal, the gene expression must be tuned greatly and effects become more robust, probably linked to the lack of experience of organisms exposed to evolutionary novel environments such as a gravitational free one. |
| first_indexed | 2025-11-14T18:18:19Z |
| format | Article |
| id | nottingham-2483 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:18:19Z |
| publishDate | 2013 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-24832020-05-04T16:37:08Z https://eprints.nottingham.ac.uk/2483/ Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis Herranz, Raul Larkin, Oliver J. Hill, Richard J.A. Lopez-Vidriero, Irene van Loon, Jack J.W.A. Medina, F. Javier Background Previous experiments have shown that the reduced gravity aboard the International Space Station (ISS) causes important alterations in Drosophila gene expression. These changes were shown to be intimately linked to environmental space-flight related constraints. Results Here, we use an array of different techniques for ground-based simulation of microgravity effects to assess the effect of suboptimal environmental conditions on the gene expression of Drosophila in reduced gravity. A global and integrative analysis, using “gene expression dynamics inspector” (GEDI) self-organizing maps, reveals different degrees in the responses of the transcriptome when using different environmental conditions or microgravity/hypergravity simulation devices. Although the genes that are affected are different in each simulation technique, we find that the same gene ontology groups, including at least one large multigene family related with behavior, stress response or organogenesis, are over represented in each case. Conclusions These results suggest that the transcriptome as a whole can be finely tuned to gravity force. In optimum environmental conditions, the alteration of gravity has only mild effects on gene expression but when environmental conditions are far from optimal, the gene expression must be tuned greatly and effects become more robust, probably linked to the lack of experience of organisms exposed to evolutionary novel environments such as a gravitational free one. BioMed Central 2013-06-27 Article PeerReviewed Herranz, Raul, Larkin, Oliver J., Hill, Richard J.A., Lopez-Vidriero, Irene, van Loon, Jack J.W.A. and Medina, F. Javier (2013) Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis. BMC Evolutionary Biology, 13 (June). 10/1-10/10. ISSN 1471-2148 Evolutionary genomics Gene family evolution Microgravity-hypergravity Magnetic levitation Gene expression Microarray http://www.biomedcentral.com/1471-2148/13/133 doi:10.1186/1471-2148-13-133 doi:10.1186/1471-2148-13-133 |
| spellingShingle | Evolutionary genomics Gene family evolution Microgravity-hypergravity Magnetic levitation Gene expression Microarray Herranz, Raul Larkin, Oliver J. Hill, Richard J.A. Lopez-Vidriero, Irene van Loon, Jack J.W.A. Medina, F. Javier Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis |
| title | Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis |
| title_full | Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis |
| title_fullStr | Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis |
| title_full_unstemmed | Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis |
| title_short | Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis |
| title_sort | suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during drosophila metamorphosis |
| topic | Evolutionary genomics Gene family evolution Microgravity-hypergravity Magnetic levitation Gene expression Microarray |
| url | https://eprints.nottingham.ac.uk/2483/ https://eprints.nottingham.ac.uk/2483/ https://eprints.nottingham.ac.uk/2483/ |