Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement

Nuclease colicins bind their target receptor BtuB in the outer membrane of sensitive Escherichia coli cells in the form of a high-affinity complex with their cognate immunity proteins. The release of the immunity protein from the colicin complex is a prerequisite for cell entry of the colicin and oc...

Full description

Bibliographic Details
Main Authors: Vankemmelbeke, Mireille, Housden, Nicholas G., James, Richard, Kleanthous, Colin, Penfold, Christopher N.
Format: Article
Published: Wiley Open Access 2013
Online Access:https://eprints.nottingham.ac.uk/2444/