Helicobacter pylori down-regulates expression of human ß-defensin 1 in the gastric mucosa in a type IV secretion dependent fashion

Helicobacter pylori down-regulates expression of human ß-defensin 1 in the gastric mucosa in a type IV secretion dependent fashion

Helicobacter pylori establishes a chronic lifelong infection in the human gastric mucosa, which may lead to peptic ulcer disease or gastric adenocarcinoma. The human beta-defensins (hβDs) are antimicrobial peptides, hβD1 being constitutively expressed in the human stomach. We hypothesized that H. py...

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Bibliographic Details
Main Authors: Patel, S.R., Smith, K., Letley, D.P., Cook, K.W., Memon, A.A., Ingram, R.J.M., Staples, E., Backert, S., Zaltoun, A.M., Atherton, J.C., Robinson, K.
Format: Article
Published: Wiley 2013
Online Access:https://eprints.nottingham.ac.uk/2410/

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