Expression of a large LINE-1-driven antisense RNA
is linked to epigenetic silencing of the metastasis
suppressor gene TFPI-2 in cancer

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Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer

LINE-1 retrotransposons are abundant repetitive elements of viral origin, which in normal cells are kept quiescent through epigenetic mechanisms. Activation of LINE-1 occurs frequently in cancer and can enable LINE-1 mobilization but also has retrotransposition-independent consequences. We pre...

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Bibliographic Details
Main Authors:	Cruickshanks, H.A, Vafadar-Isfahani, N., Dunican, D.S., Lee, A., Sproul, D., Lund, Jonathan N., Meehan, R.R., Tufarelli, C.
Format:	Article
Published:	Oxford Journals
Online Access:	https://eprints.nottingham.ac.uk/2212/

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