Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer
LINE-1 retrotransposons are abundant repetitive elements of viral origin, which in normal cells are kept quiescent through epigenetic mechanisms. Activation of LINE-1 occurs frequently in cancer and can enable LINE-1 mobilization but also has retrotransposition-independent consequences. We pre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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Oxford Journals
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| Online Access: | https://eprints.nottingham.ac.uk/2212/ |