Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework
The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows...
| Main Authors: | , , |
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| Format: | Article |
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2005
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| Online Access: | https://eprints.nottingham.ac.uk/210/ |
| _version_ | 1848790370892120064 |
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| author | Timofeeva, Yulia Lord, Gabriel Coombes, Stephen |
| author_facet | Timofeeva, Yulia Lord, Gabriel Coombes, Stephen |
| author_sort | Timofeeva, Yulia |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns. |
| first_indexed | 2025-11-14T18:11:33Z |
| format | Article |
| id | nottingham-210 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:11:33Z |
| publishDate | 2005 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-2102020-05-04T20:30:32Z https://eprints.nottingham.ac.uk/210/ Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework Timofeeva, Yulia Lord, Gabriel Coombes, Stephen The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns. 2005-10 Article PeerReviewed Timofeeva, Yulia, Lord, Gabriel and Coombes, Stephen (2005) Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework. spike-diffuse-spike dendritic spines saltatory waves noise |
| spellingShingle | spike-diffuse-spike dendritic spines saltatory waves noise Timofeeva, Yulia Lord, Gabriel Coombes, Stephen Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework |
| title | Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework |
| title_full | Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework |
| title_fullStr | Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework |
| title_full_unstemmed | Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework |
| title_short | Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework |
| title_sort | dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework |
| topic | spike-diffuse-spike dendritic spines saltatory waves noise |
| url | https://eprints.nottingham.ac.uk/210/ |