Total synthesis of argyrin A and analogues thereof

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Total synthesis of argyrin A and analogues thereof

The cyclin dependent kinase inhibitor p27 is one of the most frequently dysregulated tumour suppressor protein in human cancers. A reduction in the level of cellular p27 is frequently due to increased proteasome-dependent degradation. Recently, studies show that the macrocyclic octapeptide argyrin A...

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Bibliographic Details
Main Author:	Chen, Chou-Hsiung
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2013
Online Access:	https://eprints.nottingham.ac.uk/13296/

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