Total synthesis of argyrin A and analogues thereof
The cyclin dependent kinase inhibitor p27 is one of the most frequently dysregulated tumour suppressor protein in human cancers. A reduction in the level of cellular p27 is frequently due to increased proteasome-dependent degradation. Recently, studies show that the macrocyclic octapeptide argyrin A...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2013
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| Online Access: | https://eprints.nottingham.ac.uk/13296/ |