Transcriptional analysis of the human D4Z4 and mouse Dux arrays

Facioscapulohumeral muscular dystrophy (FSHD) is the third most common form of muscular dystrophy in Caucasians. FSHD is caused by contraction of a 3.3kb repeat array, D4Z4, to below 11 repeat units. Each of these repeat units contains an ORF encoding the DUX4 gene and at the beginning of the work d...

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Bibliographic Details
Main Author: Hampson, Amanda
Format: Thesis (University of Nottingham only)
Language:English
Published: 2012
Online Access:https://eprints.nottingham.ac.uk/12784/