Repolarisation of the immune-suppressive millieu of the ovarian tumour using targeted therapeutics

QR Code

Repolarisation of the immune-suppressive millieu of the ovarian tumour using targeted therapeutics

Ovarian cancer is a disease which is fatal in the majority of cases. The evolution of surgery and chemotherapy over the past 30 years has resulted in improvements in overall and progression-free survival. However, the rate of relapse in ovarian cancer is very high, suggesting that current treatment...

Full description

Bibliographic Details
Main Author:	Khan, Adnan R.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2012
Subjects:	Cancer Immunology Ovarian CCR4 Regulatory T cell MUC1 Camptothecin Plasmacytoid Dendritic Cell Toll-like receptors
Online Access:	https://eprints.nottingham.ac.uk/12463/

Similar Items

Subset-specific expression of toll-like receptors by bovine afferent lymph dendritic cells
by: Werling, Dirk, et al.
Published: (2017)

Identification and characterization of toll-like receptor (TLR) 2 and 4 mutations in colorectal
by: Davoodi, Homa
Published: (2009)

Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs)
by: Almousa, Lujain A., et al.
Published: (2018)

Investigating the initiation & progression of ulcerative colitis
by: Fair, Kathryn L.
Published: (2024)

The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization
by: Salazar, Fabián, et al.
Published: (2016)

RNA expression of TLR10 in normal equine tissues
by: Tarlinton, Rachael E., et al.
Published: (2016)

Immune modulatory properties of nanoparticles on human dendritic cells
by: Al-Zahri, Reem
Published: (2018)

Toll-like receptors (TLRs) and T cell effector function
by: Mahmood, Majid Mohammed
Published: (2020)

Characterisation of novel TLR-dependent immunomodulators from tropical plant extracts
by: Thirlaway, Khalil
Published: (2018)

Immune instructive materials for dendritic cell modulation
by: Kämmerling, Lisa
Published: (2021)

Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
by: Zhang, Fu-Kai, et al.
Published: (2018)

The role of indoleamine 2,3-dioxygenase in modulating allergic responses
by: Salazar, F.
Published: (2016)

The novel roles of DNA damage repair proteins ATM and DNA-PK in the regulation of the ER stress response and IL-23 expression in dendritic cells
by: Shah, Sabaria
Published: (2017)

Enhanced dendritic cell immunotherapy to treat glioblastoma
by: Adhikaree, Jason
Published: (2019)

Discovering novel immune-modulatory monosaccharides using high-throughput screening strategies
by: Alobaid, Meshal
Published: (2020)

Physiochemical characterization and anticancer efficacy of camptothecin loaded β-Cyclodextrin-EDTA-Fe₃O₄ nanocarrier
by: Krishnan, Poorani
Published: (2017)

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis
by: Amer, Saad A., et al.
Published: (2017)

Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy
by: Rauch, Cyril, et al.
Published: (2013)

Impact of p38 mitogen-activated protein kinase inhibition on immunostimulatory properties of human 6-sulfo LacNAc dendritic cells
by: Langosch, Saskia, et al.
Published: (2016)

Linking the westernised oropharyngeal microbiome to the immune response in Chinese immigrants
by: Guo, Jing, et al.
Published: (2020)

Development of biomimetic platforms to investigate the influence of the extra-cellular environment on immunological responses
by: Donaldson, Amy Rose
Published: (2017)

Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma patients.
by: Seow, Heng Fong, et al.
Published: (2009)

The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review
by: Mohamed, Ahmed A., et al.
Published: (2016)

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle
by: Dai, Yanzhenzi, et al.
Published: (2017)

Development of nanoparticles for targeted delivery of p38 MAPK inhibitor to myeloid dendritic cells
by: You, Jinge
Published: (2024)

Delivery of imiquimod to intestinal lymph nodes following oral administration
by: Chen, Haojie
Published: (2025)

Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists
by: Kindon, Nicholas, et al.
Published: (2017)

Inhibition of the p38 MAPK pathway as a strategy to overcome tumour immune suppression in CD1c+ dendritic cells
by: Chisanga, Chrispin
Published: (2024)

The influence of stromal fibroblast on antigen-presenting cell function and alteration of their biology
by: Mohammad, Salaheddin
Published: (2022)

25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life
by: Jones, A., et al.
Published: (2015)

The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment
by: Yaşayan, Gökçen, et al.
Published: (2016)

Risk factors of ovarian cancer among women at selected hospitals in the Klang Valley, Malaysia
by: John, Ugwu Osmong
Published: (2019)

The impact of stroma and ionising radiation on the plasticity of dendritic cells and macrophages
by: Malecka, Anna A.
Published: (2018)

Human dendritic cell sequestration onto the Necator americanus larval sheath during ex-sheathing: a possible mechanism for immune privilege
by: Hassan, A., et al.
Published: (2018)

Lipid-laden partially-activated plasmacytoid and CD4-CD8a+ dendritic cells accumulate in tissues in elderly mice
by: Gardner, Joanne, et al.
Published: (2014)

Development of a human induced pluripotent stem cells (hiPSCs)-derived, universal platform, for generation of immunocompetent multi-tissue organoids
by: Azis, Rizal
Published: (2024)

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation
by: Chatzigeorgiou, Antonios, et al.
Published: (2014)

'Introducing Dendritic Cells as a Novel Immune-Inspired Algorithm for Anomaly Detection'
by: Greensmith, Julie, et al.
Published: (2005)

'Introducing Dendritic Cells as a Novel Immune-Inspired Algorithm for Anomaly Detection'
by: Greensmith, Julie, et al.
Published: (2005)

Mesenchymal stem cell and microglia crosstalk in an inflammatory paradigm
by: Rahmat, Muhammad Zul'atfi
Published: (2013)