Small molecule inhibitors of Mdm2 E3 ubiquitin ligase activity

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Small molecule inhibitors of Mdm2 E3 ubiquitin ligase activity

Half of cancers retain wild type p53 but have alterations in the pathways involved in p53 regulation. Murine double minute 2 (Mdm2) regulates p53 by acting as an E3 ubiquitin ligase, which tags p53 for degradation through the proteasome. A small molecule inhibitor, a 5-deazaflavin analogue, has prev...

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Bibliographic Details
Main Author:	Dickens, Michael
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2011
Online Access:	https://eprints.nottingham.ac.uk/11960/

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