Species-specific kinetics and zonation of hepatic
DNA synthesis induced by ligands of PPARα

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Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARα

PPARα ligands evoke a profound mitogenic response in rodent liver, and the aim of this study was to characterise the kinetics of induction of DNA synthesis. The CAR ligand, 1,4-bis[2-(3,5- dichoropyridyloxy)]benzene, caused induction of hepatocyte DNA synthesis within 48 hours in 129S4/SvJae mice...

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Bibliographic Details
Main Authors:	Al Kholaifi, Abdullah, Amer, Abeer, Jeffery, Brett, Gray, Tim J.B., Roberts, Ruth A., Bell, David Robert
Format:	Article
Published:	Oxford University Press 2008
Online Access:	https://eprints.nottingham.ac.uk/1068/

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