Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARα
PPARα ligands evoke a profound mitogenic response in rodent liver, and the aim of this study was to characterise the kinetics of induction of DNA synthesis. The CAR ligand, 1,4-bis[2-(3,5- dichoropyridyloxy)]benzene, caused induction of hepatocyte DNA synthesis within 48 hours in 129S4/SvJae mice...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Oxford University Press
2008
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| Online Access: | https://eprints.nottingham.ac.uk/1068/ |