Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics
Fruit of salak (Salacca zalacca) is tradition ally used and commercialized as an an tidiabetic agent. How ever, the scientific evidence to prove this traditional use is lack ing. This re search was aimed to evaluate the metabolic changes of obese-diabetic (OBDC) rats treated with S. zalacca fruit...
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| Format: | Article |
| Language: | English English English English |
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Elseviers
2020
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| Online Access: | http://irep.iium.edu.my/81676/ http://irep.iium.edu.my/81676/7/evidence%20email-jamshed.pdf http://irep.iium.edu.my/81676/13/1-s2.0-S096399692030572X-main.pdf http://irep.iium.edu.my/81676/19/81676_Modulation%20of%20metabolic%20alterations%20of%20obese_scopus.pdf http://irep.iium.edu.my/81676/25/81676_Modulation%20of%20metabolic%20alterations%20of%20obese%20diabetic%20rats_WoS.pdf |
| _version_ | 1848789165473267712 |
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| author | Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mediani, Ahmed Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Saidi-Besbes, Salima Elnaem, Mohamed Hassan Abdelaziz Othman, Hairol Azrin Ismail, Nor Hadiani |
| author_facet | Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mediani, Ahmed Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Saidi-Besbes, Salima Elnaem, Mohamed Hassan Abdelaziz Othman, Hairol Azrin Ismail, Nor Hadiani |
| author_sort | Saleh, Mohammed S M |
| building | IIUM Repository |
| collection | Online Access |
| description | Fruit of salak (Salacca zalacca) is tradition ally used and commercialized as an an tidiabetic agent. How ever,
the scientific evidence to prove this traditional use is lack ing. This re search was aimed to evaluate the
metabolic changes of obese-diabetic (OBDC) rats treated with S. zalacca fruit using proton-nuclear magnetic
resonance ( H NMR)-based metabolomics approach. This re search presents the first report on the in vitro
antidiabetic effect of S. zalacca fruits ex tract us ing this approach. The obtained results in dicated that the
administration of 400 mg/ kg bw of 60% ethanolic S. zalacca extract for 6 weeks significantly de creased the
blood glucose level and normalized the blood lipid pro file of the OBDC rats. The potential biomarkers in
urine were 2-oxoglutarate, alanine, leucine, succinate 3-hydroxy butyrate, taurine, betaine, allantoin, acetate, dimethylamine, creatine, creatinine, glucose, phenyl-acetyl glycine, and hippurate. Based on the data
obtained, the metabolite pro files of the urine of treated rats by the 60% ethanolic extract could not be fully
improved the metabolic complications of diabetic rats. The ex tract of S. zalacca fruit was able to de crease
the ketones bodies as 3-hydroxy butyrate and acetoacetate. It has also improved energy metabolism, involving glucose, acetate, lactate, 2-hydroxy butyrate, 2-oxoglutarate, citrate, and succinate. More over, it decreased metabolites from gut microflora, including choline. This extract had significant effect on amino acid metabolism, metabolites from gut microflora, bile acid metabolism and creatine. The result can further
support the traditional claims of S. zalacca fruits in management of diabetes. This finding might bevaluable
in understanding the molecular mechanism and pharmacological properties of this medicinal plant for
managing diabetes mellitus. |
| first_indexed | 2025-11-14T17:52:23Z |
| format | Article |
| id | iium-81676 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English English |
| last_indexed | 2025-11-14T17:52:23Z |
| publishDate | 2020 |
| publisher | Elseviers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-816762022-07-15T02:18:51Z http://irep.iium.edu.my/81676/ Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mediani, Ahmed Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Saidi-Besbes, Salima Elnaem, Mohamed Hassan Abdelaziz Othman, Hairol Azrin Ismail, Nor Hadiani QD Chemistry Fruit of salak (Salacca zalacca) is tradition ally used and commercialized as an an tidiabetic agent. How ever, the scientific evidence to prove this traditional use is lack ing. This re search was aimed to evaluate the metabolic changes of obese-diabetic (OBDC) rats treated with S. zalacca fruit using proton-nuclear magnetic resonance ( H NMR)-based metabolomics approach. This re search presents the first report on the in vitro antidiabetic effect of S. zalacca fruits ex tract us ing this approach. The obtained results in dicated that the administration of 400 mg/ kg bw of 60% ethanolic S. zalacca extract for 6 weeks significantly de creased the blood glucose level and normalized the blood lipid pro file of the OBDC rats. The potential biomarkers in urine were 2-oxoglutarate, alanine, leucine, succinate 3-hydroxy butyrate, taurine, betaine, allantoin, acetate, dimethylamine, creatine, creatinine, glucose, phenyl-acetyl glycine, and hippurate. Based on the data obtained, the metabolite pro files of the urine of treated rats by the 60% ethanolic extract could not be fully improved the metabolic complications of diabetic rats. The ex tract of S. zalacca fruit was able to de crease the ketones bodies as 3-hydroxy butyrate and acetoacetate. It has also improved energy metabolism, involving glucose, acetate, lactate, 2-hydroxy butyrate, 2-oxoglutarate, citrate, and succinate. More over, it decreased metabolites from gut microflora, including choline. This extract had significant effect on amino acid metabolism, metabolites from gut microflora, bile acid metabolism and creatine. The result can further support the traditional claims of S. zalacca fruits in management of diabetes. This finding might bevaluable in understanding the molecular mechanism and pharmacological properties of this medicinal plant for managing diabetes mellitus. Elseviers 2020-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/81676/7/evidence%20email-jamshed.pdf application/pdf en http://irep.iium.edu.my/81676/13/1-s2.0-S096399692030572X-main.pdf application/pdf en http://irep.iium.edu.my/81676/19/81676_Modulation%20of%20metabolic%20alterations%20of%20obese_scopus.pdf application/pdf en http://irep.iium.edu.my/81676/25/81676_Modulation%20of%20metabolic%20alterations%20of%20obese%20diabetic%20rats_WoS.pdf Saleh, Mohammed S M and Siddiqui, Mohammad Jamshed Ahmad and Mediani, Ahmed and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton and Saidi-Besbes, Salima and Elnaem, Mohamed Hassan Abdelaziz and Othman, Hairol Azrin and Ismail, Nor Hadiani (2020) Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics. Food Research International, 137. ISSN 0963-9969 https://www.sciencedirect.com/science/article/abs/pii/S096399692030572X?via%3Dihub 10.1016/j.foodres.2020.109547 |
| spellingShingle | QD Chemistry Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mediani, Ahmed Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Saidi-Besbes, Salima Elnaem, Mohamed Hassan Abdelaziz Othman, Hairol Azrin Ismail, Nor Hadiani Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics |
| title | Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics |
| title_full | Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics |
| title_fullStr | Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics |
| title_full_unstemmed | Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics |
| title_short | Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using H NMR-based metabolomics |
| title_sort | modulation of metabolic alterations of obese diabetic rats upon treatment with salacca zalacca fruits extract using h nmr-based metabolomics |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/81676/ http://irep.iium.edu.my/81676/ http://irep.iium.edu.my/81676/ http://irep.iium.edu.my/81676/7/evidence%20email-jamshed.pdf http://irep.iium.edu.my/81676/13/1-s2.0-S096399692030572X-main.pdf http://irep.iium.edu.my/81676/19/81676_Modulation%20of%20metabolic%20alterations%20of%20obese_scopus.pdf http://irep.iium.edu.my/81676/25/81676_Modulation%20of%20metabolic%20alterations%20of%20obese%20diabetic%20rats_WoS.pdf |