The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis
Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection. Previous studies have highlighted Candida albicans host tissue infection as a risk factor in the initiation and...
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| Format: | Article |
| Language: | English English English |
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John Wiley & Sons Ltd
2020
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| Online Access: | http://irep.iium.edu.my/80858/ http://irep.iium.edu.my/80858/1/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20early%20access.pdf http://irep.iium.edu.my/80858/2/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20SCOPUS%20early%20access.pdf http://irep.iium.edu.my/80858/3/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20WOS%20early%20access.pdf |
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| author | Engku Nasrullah Satiman, Engku Anis Fariha Ahmad, Hasna Ramzi, Ahmad Bazli Abdul Wahab, Ridhwan Kaderi, Mohd Arifin Wan Harun, Wan Himratul Aznita Dashper, Stuart McCullough, Michael Arzmi, Mohd Hafiz |
| author_facet | Engku Nasrullah Satiman, Engku Anis Fariha Ahmad, Hasna Ramzi, Ahmad Bazli Abdul Wahab, Ridhwan Kaderi, Mohd Arifin Wan Harun, Wan Himratul Aznita Dashper, Stuart McCullough, Michael Arzmi, Mohd Hafiz |
| author_sort | Engku Nasrullah Satiman, Engku Anis Fariha |
| building | IIUM Repository |
| collection | Online Access |
| description | Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection. Previous studies have highlighted Candida albicans host tissue infection as a risk factor in the initiation and progression of oral cancer. C. albicans invasion induces several cancerous hallmarks, such as activation of proto-oncogenes, induction of DNA damage and overexpression of inflammatory signalling pathways. However, the molecular mechanisms behind these responses remain unclear. A recently discovered fungal toxin peptide, candidalysin, has been reported as an essential molecule in epithelial damage and host recognition of C albicans infection. Candidalysin has a clear role in inflammasome activation and induction of cell damage. Several inflammatory molecules such as IL-6, IL-17, NLRP3 and GM-CSF have been linked to carcinogenesis. Candidalysin is encoded by the ECE1 gene, which has been linked to virulence factors of C albicans such as adhesion, biofilm formation and filamentation properties. This review discusses the recent epidemiological burden of oral cancer and highlights the significance of the ECE1 gene and the ECE1 protein breakdown product, candidalysin in oral malignancy. The immunological and molecular mechanisms behind oral malignancy induced by inflammation and the role of the toxic fungal peptide candidalysin in oral carcinogenesis are explored. With increasing evidence associating C albicans with oral carcinoma, identifying the possible fungal pathogenicity factors including the role of candidalysin can assist in efforts to understand the link between C albicans infection and carcinogenesis, and pave the way for research into therapeutic potentials. |
| first_indexed | 2025-11-14T17:50:17Z |
| format | Article |
| id | iium-80858 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:50:17Z |
| publishDate | 2020 |
| publisher | John Wiley & Sons Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-808582022-06-03T03:19:51Z http://irep.iium.edu.my/80858/ The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis Engku Nasrullah Satiman, Engku Anis Fariha Ahmad, Hasna Ramzi, Ahmad Bazli Abdul Wahab, Ridhwan Kaderi, Mohd Arifin Wan Harun, Wan Himratul Aznita Dashper, Stuart McCullough, Michael Arzmi, Mohd Hafiz QR Microbiology RK Dentistry Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection. Previous studies have highlighted Candida albicans host tissue infection as a risk factor in the initiation and progression of oral cancer. C. albicans invasion induces several cancerous hallmarks, such as activation of proto-oncogenes, induction of DNA damage and overexpression of inflammatory signalling pathways. However, the molecular mechanisms behind these responses remain unclear. A recently discovered fungal toxin peptide, candidalysin, has been reported as an essential molecule in epithelial damage and host recognition of C albicans infection. Candidalysin has a clear role in inflammasome activation and induction of cell damage. Several inflammatory molecules such as IL-6, IL-17, NLRP3 and GM-CSF have been linked to carcinogenesis. Candidalysin is encoded by the ECE1 gene, which has been linked to virulence factors of C albicans such as adhesion, biofilm formation and filamentation properties. This review discusses the recent epidemiological burden of oral cancer and highlights the significance of the ECE1 gene and the ECE1 protein breakdown product, candidalysin in oral malignancy. The immunological and molecular mechanisms behind oral malignancy induced by inflammation and the role of the toxic fungal peptide candidalysin in oral carcinogenesis are explored. With increasing evidence associating C albicans with oral carcinoma, identifying the possible fungal pathogenicity factors including the role of candidalysin can assist in efforts to understand the link between C albicans infection and carcinogenesis, and pave the way for research into therapeutic potentials. John Wiley & Sons Ltd 2020-03-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/80858/1/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20early%20access.pdf application/pdf en http://irep.iium.edu.my/80858/2/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20SCOPUS%20early%20access.pdf application/pdf en http://irep.iium.edu.my/80858/3/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20WOS%20early%20access.pdf Engku Nasrullah Satiman, Engku Anis Fariha and Ahmad, Hasna and Ramzi, Ahmad Bazli and Abdul Wahab, Ridhwan and Kaderi, Mohd Arifin and Wan Harun, Wan Himratul Aznita and Dashper, Stuart and McCullough, Michael and Arzmi, Mohd Hafiz (2020) The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis. Journal of Oral Pathology and Medicine, xx. pp. 1-7. E-ISSN 1600-0714 (In Press) https://onlinelibrary.wiley.com/doi/10.1111/jop.13014 https://doi.org/10.1111/jop.13014 |
| spellingShingle | QR Microbiology RK Dentistry Engku Nasrullah Satiman, Engku Anis Fariha Ahmad, Hasna Ramzi, Ahmad Bazli Abdul Wahab, Ridhwan Kaderi, Mohd Arifin Wan Harun, Wan Himratul Aznita Dashper, Stuart McCullough, Michael Arzmi, Mohd Hafiz The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis |
| title | The role of Candida albicans candidalysin ECE1 gene in oral
carcinogenesis |
| title_full | The role of Candida albicans candidalysin ECE1 gene in oral
carcinogenesis |
| title_fullStr | The role of Candida albicans candidalysin ECE1 gene in oral
carcinogenesis |
| title_full_unstemmed | The role of Candida albicans candidalysin ECE1 gene in oral
carcinogenesis |
| title_short | The role of Candida albicans candidalysin ECE1 gene in oral
carcinogenesis |
| title_sort | role of candida albicans candidalysin ece1 gene in oral
carcinogenesis |
| topic | QR Microbiology RK Dentistry |
| url | http://irep.iium.edu.my/80858/ http://irep.iium.edu.my/80858/ http://irep.iium.edu.my/80858/ http://irep.iium.edu.my/80858/1/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20early%20access.pdf http://irep.iium.edu.my/80858/2/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20SCOPUS%20early%20access.pdf http://irep.iium.edu.my/80858/3/80858_The%20role%20of%20Candida%20albicans%20candidalysin-%20WOS%20early%20access.pdf |