Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review
Malaria continues to pose imminent threat to the world population, as the mortality rate associated with this disease remains high. Current treatment relies on antimalarial drugs such as Artemisinin Combination Therapy (ACT) are still effective throughout the world except in some places, where ACT-r...
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| Format: | Article |
| Language: | English English |
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University of Malaya
2019
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| Online Access: | http://irep.iium.edu.my/79762/ http://irep.iium.edu.my/79762/1/79762_Plasmodial%20enzymes%20in%20metabolic.pdf http://irep.iium.edu.my/79762/2/79762_Plasmodial%20enzymes%20in%20metabolic_SCOPUS.pdf |
| _version_ | 1848788835327016960 |
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| author | Ogu Salim, Nurhainis Md Yusuf, Noor Azian Ahmad Fuad, Fazia Adyani |
| author_facet | Ogu Salim, Nurhainis Md Yusuf, Noor Azian Ahmad Fuad, Fazia Adyani |
| author_sort | Ogu Salim, Nurhainis |
| building | IIUM Repository |
| collection | Online Access |
| description | Malaria continues to pose imminent threat to the world population, as the mortality rate associated with this disease remains high. Current treatment relies on antimalarial drugs such as Artemisinin Combination Therapy (ACT) are still effective throughout the world except in some places, where ACT-resistance has been reported, thus necessitating novel approaches to develop new anti-malarial therapy. In the light of emerging translational research, several plasmodial targets, mostly proteins or enzymes located in the parasite’s unique organelles, have been extensively explored as potential candidates for the development of novel antimalarial drugs. By targeting the metabolic pathways in mitochondrion, apicoplast or cytoplasm of Plasmodium, the possibility to discover new drugs is tremendous, as they have potentials as antimalarial therapeutic targets. This literature review summarizes pertinent information on plasmodial targets, especially enzymes involved in specific metabolic pathways, and the strategies used to discover new antimalarial drugs. © 2019, University of Malaya. All rights reserved. |
| first_indexed | 2025-11-14T17:47:08Z |
| format | Article |
| id | iium-79762 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:47:08Z |
| publishDate | 2019 |
| publisher | University of Malaya |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-797622020-03-23T15:27:28Z http://irep.iium.edu.my/79762/ Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review Ogu Salim, Nurhainis Md Yusuf, Noor Azian Ahmad Fuad, Fazia Adyani TP248.13 Biotechnology Malaria continues to pose imminent threat to the world population, as the mortality rate associated with this disease remains high. Current treatment relies on antimalarial drugs such as Artemisinin Combination Therapy (ACT) are still effective throughout the world except in some places, where ACT-resistance has been reported, thus necessitating novel approaches to develop new anti-malarial therapy. In the light of emerging translational research, several plasmodial targets, mostly proteins or enzymes located in the parasite’s unique organelles, have been extensively explored as potential candidates for the development of novel antimalarial drugs. By targeting the metabolic pathways in mitochondrion, apicoplast or cytoplasm of Plasmodium, the possibility to discover new drugs is tremendous, as they have potentials as antimalarial therapeutic targets. This literature review summarizes pertinent information on plasmodial targets, especially enzymes involved in specific metabolic pathways, and the strategies used to discover new antimalarial drugs. © 2019, University of Malaya. All rights reserved. University of Malaya 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/79762/1/79762_Plasmodial%20enzymes%20in%20metabolic.pdf application/pdf en http://irep.iium.edu.my/79762/2/79762_Plasmodial%20enzymes%20in%20metabolic_SCOPUS.pdf Ogu Salim, Nurhainis and Md Yusuf, Noor Azian and Ahmad Fuad, Fazia Adyani (2019) Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (4). pp. 38-53. E-ISSN 0128-7451 http://msmbb.my/images/publication/volume_27/issue_4/05-Salim-et-al.pdf |
| spellingShingle | TP248.13 Biotechnology Ogu Salim, Nurhainis Md Yusuf, Noor Azian Ahmad Fuad, Fazia Adyani Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review |
| title | Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review |
| title_full | Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review |
| title_fullStr | Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review |
| title_full_unstemmed | Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review |
| title_short | Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review |
| title_sort | plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review |
| topic | TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/79762/ http://irep.iium.edu.my/79762/ http://irep.iium.edu.my/79762/1/79762_Plasmodial%20enzymes%20in%20metabolic.pdf http://irep.iium.edu.my/79762/2/79762_Plasmodial%20enzymes%20in%20metabolic_SCOPUS.pdf |