Metastasis within a metastasis to the thyroid: A rare phenomenon
Metastatic disease involving the thyroid gland is uncommon. Solitary thyroid metastases from various primary sites particularly kidney, lung, and breast had been previously described. To the best of our knowledge, metastases from two topographically separate primary malignancies to the thyroid have...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer - Medknow
2017
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| Online Access: | http://irep.iium.edu.my/77512/ http://irep.iium.edu.my/77512/1/Metastasis%20within%20a%20metastasis%20to%20the%20thyroid_%20A%20rare%20phenomenon%20_%5BPAUTHORS%5D%2C%20Indian%20Journal%20of%20Pathology%20and%20Microbiology%20%28IJPM%29.pdf |
| _version_ | 1848788455284277248 |
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| author | Wong, Yin PIng Ahmad Affandi, Khairunisa Tan, Geok Chin Muhammad, Rohaizak |
| author_facet | Wong, Yin PIng Ahmad Affandi, Khairunisa Tan, Geok Chin Muhammad, Rohaizak |
| author_sort | Wong, Yin PIng |
| building | IIUM Repository |
| collection | Online Access |
| description | Metastatic disease involving the thyroid gland is uncommon. Solitary thyroid metastases from various primary sites particularly kidney, lung, and breast had been previously described. To the best of our knowledge, metastases from two topographically separate primary malignancies to the thyroid have never been documented hitherto. This is the first reported case of cancer-to-cancer metastasis involving an invasive breast carcinoma metastasized within a metastatic renal cell carcinoma in the nonneoplastic thyroid in a 58-year-old woman. Distinguishing a secondary thyroid metastases from a primary thyroid malignancy is utmost crucial as treatment differs. The possibility of tumor metastases from two separated primaries should always be considered in a tumor exhibiting malignant cell populations with two distinctive histomorphological appearances. The role of immunohistochemistry stains in equivocal cases cannot be overemphasized. |
| first_indexed | 2025-11-14T17:41:06Z |
| format | Article |
| id | iium-77512 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:41:06Z |
| publishDate | 2017 |
| publisher | Wolters Kluwer - Medknow |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-775122020-02-14T02:28:22Z http://irep.iium.edu.my/77512/ Metastasis within a metastasis to the thyroid: A rare phenomenon Wong, Yin PIng Ahmad Affandi, Khairunisa Tan, Geok Chin Muhammad, Rohaizak R Medicine (General) Metastatic disease involving the thyroid gland is uncommon. Solitary thyroid metastases from various primary sites particularly kidney, lung, and breast had been previously described. To the best of our knowledge, metastases from two topographically separate primary malignancies to the thyroid have never been documented hitherto. This is the first reported case of cancer-to-cancer metastasis involving an invasive breast carcinoma metastasized within a metastatic renal cell carcinoma in the nonneoplastic thyroid in a 58-year-old woman. Distinguishing a secondary thyroid metastases from a primary thyroid malignancy is utmost crucial as treatment differs. The possibility of tumor metastases from two separated primaries should always be considered in a tumor exhibiting malignant cell populations with two distinctive histomorphological appearances. The role of immunohistochemistry stains in equivocal cases cannot be overemphasized. Wolters Kluwer - Medknow 2017-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77512/1/Metastasis%20within%20a%20metastasis%20to%20the%20thyroid_%20A%20rare%20phenomenon%20_%5BPAUTHORS%5D%2C%20Indian%20Journal%20of%20Pathology%20and%20Microbiology%20%28IJPM%29.pdf Wong, Yin PIng and Ahmad Affandi, Khairunisa and Tan, Geok Chin and Muhammad, Rohaizak (2017) Metastasis within a metastasis to the thyroid: A rare phenomenon. Indian Journal of Pathology & Microbiology, 60 (3 (July-September)). pp. 1-2. ISSN 0377-4929 http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=3;spage=430;epage=432;aulast=Wong;type=0 10.4103/IJPM.IJPM_287_16 |
| spellingShingle | R Medicine (General) Wong, Yin PIng Ahmad Affandi, Khairunisa Tan, Geok Chin Muhammad, Rohaizak Metastasis within a metastasis to the thyroid: A rare phenomenon |
| title | Metastasis within a metastasis to the thyroid: A rare phenomenon |
| title_full | Metastasis within a metastasis to the thyroid: A rare phenomenon |
| title_fullStr | Metastasis within a metastasis to the thyroid: A rare phenomenon |
| title_full_unstemmed | Metastasis within a metastasis to the thyroid: A rare phenomenon |
| title_short | Metastasis within a metastasis to the thyroid: A rare phenomenon |
| title_sort | metastasis within a metastasis to the thyroid: a rare phenomenon |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/77512/ http://irep.iium.edu.my/77512/ http://irep.iium.edu.my/77512/ http://irep.iium.edu.my/77512/1/Metastasis%20within%20a%20metastasis%20to%20the%20thyroid_%20A%20rare%20phenomenon%20_%5BPAUTHORS%5D%2C%20Indian%20Journal%20of%20Pathology%20and%20Microbiology%20%28IJPM%29.pdf |