Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
Prostaglandin E2 (PGE2) is an essential metabolite of the cyclooxygenase pathway in the human body. However, excessive production of PGE2 has been implicated with a variety of inflammatory and cancer diseases. Studies have revealed that blockade of PGE2 production could enhance the innate immune fun...
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| Format: | Proceeding Paper |
| Language: | English English English English |
| Published: |
2019
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| Online Access: | http://irep.iium.edu.my/77275/ http://irep.iium.edu.my/77275/1/Abstract.pdf http://irep.iium.edu.my/77275/2/1st-MSC-3-4-Dec-2019-third-announcement.jpg http://irep.iium.edu.my/77275/3/Abstract%20Acceptance%20Letter.pdf http://irep.iium.edu.my/77275/4/Presentation_MACR.pdf |
| _version_ | 1848788412130131968 |
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| author | Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam |
| author_facet | Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam |
| author_sort | Rullah, Kamal |
| building | IIUM Repository |
| collection | Online Access |
| description | Prostaglandin E2 (PGE2) is an essential metabolite of the cyclooxygenase pathway in the human body. However, excessive production of PGE2 has been implicated with a variety of inflammatory and cancer diseases. Studies have revealed that blockade of PGE2 production could enhance the innate immune function both in vitro and ex vivo experiments. Hence, this could serve as a useful strategy for preventing and treating inflammation and cancer in related individuals. Natural products have been of great interest for many years, and have provided modern medicine with numerous useful drug leads. One of the families of natural products that has been widely explored for their biological activities is the chromones. |
| first_indexed | 2025-11-14T17:40:25Z |
| format | Proceeding Paper |
| id | iium-77275 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English English |
| last_indexed | 2025-11-14T17:40:25Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-772752019-12-19T07:01:12Z http://irep.iium.edu.my/77275/ Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam RS403 Materia Medica-Pharmaceutical Chemistry Prostaglandin E2 (PGE2) is an essential metabolite of the cyclooxygenase pathway in the human body. However, excessive production of PGE2 has been implicated with a variety of inflammatory and cancer diseases. Studies have revealed that blockade of PGE2 production could enhance the innate immune function both in vitro and ex vivo experiments. Hence, this could serve as a useful strategy for preventing and treating inflammation and cancer in related individuals. Natural products have been of great interest for many years, and have provided modern medicine with numerous useful drug leads. One of the families of natural products that has been widely explored for their biological activities is the chromones. 2019-12-03 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/77275/1/Abstract.pdf application/pdf en http://irep.iium.edu.my/77275/2/1st-MSC-3-4-Dec-2019-third-announcement.jpg application/pdf en http://irep.iium.edu.my/77275/3/Abstract%20Acceptance%20Letter.pdf application/pdf en http://irep.iium.edu.my/77275/4/Presentation_MACR.pdf Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Kok Wai, Lam (2019) Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production. In: 1st Malaysian Association for Cancer Research (MACR) Scientific Conference (1st MSC) 2019, 3th-4th December 2019, MAHSA University, Bandar Saujana Putra, Selangor. (Unpublished) |
| spellingShingle | RS403 Materia Medica-Pharmaceutical Chemistry Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production |
| title | Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production |
| title_full | Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production |
| title_fullStr | Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production |
| title_full_unstemmed | Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production |
| title_short | Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production |
| title_sort | synthesis and sar studies of new chromone derivatives as inhibitors of pge2 production |
| topic | RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/77275/ http://irep.iium.edu.my/77275/1/Abstract.pdf http://irep.iium.edu.my/77275/2/1st-MSC-3-4-Dec-2019-third-announcement.jpg http://irep.iium.edu.my/77275/3/Abstract%20Acceptance%20Letter.pdf http://irep.iium.edu.my/77275/4/Presentation_MACR.pdf |