Factors associated with quality of life (QOL) in Huntington’s disease (HD).
Background: Huntington’s disease (HD) is an inherited progressive neurodegenerative disorder which affects motor function, cognition and the psychological state of HD patients. Its triad of unique symptoms compared to other neurodegenerative disorders might give rise to a higher level of burden for...
| Main Authors: | , , , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/75412/ http://irep.iium.edu.my/75412/1/full.pdf |
| _version_ | 1848788122553286656 |
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| author | Md Rosli, Najwa Hanim Mangelsdorf, Simone Farrand, Sarah Loi, Samantha M Eratne, Dhamidhu Velakoulis, Dennis |
| author_facet | Md Rosli, Najwa Hanim Mangelsdorf, Simone Farrand, Sarah Loi, Samantha M Eratne, Dhamidhu Velakoulis, Dennis |
| author_sort | Md Rosli, Najwa Hanim |
| building | IIUM Repository |
| collection | Online Access |
| description | Background:
Huntington’s disease (HD) is an inherited progressive neurodegenerative disorder which affects motor function, cognition and the psychological state of HD patients. Its triad of unique symptoms compared to other neurodegenerative disorders might give rise to a higher level of burden for their carers.
Aims:
The aim of this study was to explore factors associated with the quality of life in patients with HD.
Methods:
Sixty-three HD patients and their carers participated in this study. Cognitive impairment was assessed with the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG), motor disturbances was scored using the Unified Huntington’s Disease Rating Scale (UHDRS) motor scale, psychological status of both patient and carer were assessed using the Depression Anxiety Stress scale (DASS21), behavior of the patient was assessed using Revised Cambridge Behavioural Inventory (CBI-r) and patient’s quality of life was assessed with WHOQOL-BREF questionnaire.
Results:
Patients’ psychological conditions, motor disturbances and behavior of the patient are correlated with low QOL in HD patient.
Conclusion:
Patients’ factors are more likely to affect QOL in HD patient compared to carers’ factors; motor and psychological symptoms are key. |
| first_indexed | 2025-11-14T17:35:48Z |
| format | Proceeding Paper |
| id | iium-75412 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:35:48Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-754122019-11-18T07:27:46Z http://irep.iium.edu.my/75412/ Factors associated with quality of life (QOL) in Huntington’s disease (HD). Md Rosli, Najwa Hanim Mangelsdorf, Simone Farrand, Sarah Loi, Samantha M Eratne, Dhamidhu Velakoulis, Dennis RZ Other systems of medicine Background: Huntington’s disease (HD) is an inherited progressive neurodegenerative disorder which affects motor function, cognition and the psychological state of HD patients. Its triad of unique symptoms compared to other neurodegenerative disorders might give rise to a higher level of burden for their carers. Aims: The aim of this study was to explore factors associated with the quality of life in patients with HD. Methods: Sixty-three HD patients and their carers participated in this study. Cognitive impairment was assessed with the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG), motor disturbances was scored using the Unified Huntington’s Disease Rating Scale (UHDRS) motor scale, psychological status of both patient and carer were assessed using the Depression Anxiety Stress scale (DASS21), behavior of the patient was assessed using Revised Cambridge Behavioural Inventory (CBI-r) and patient’s quality of life was assessed with WHOQOL-BREF questionnaire. Results: Patients’ psychological conditions, motor disturbances and behavior of the patient are correlated with low QOL in HD patient. Conclusion: Patients’ factors are more likely to affect QOL in HD patient compared to carers’ factors; motor and psychological symptoms are key. 2019-10-09 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/75412/1/full.pdf Md Rosli, Najwa Hanim and Mangelsdorf, Simone and Farrand, Sarah and Loi, Samantha M and Eratne, Dhamidhu and Velakoulis, Dennis (2019) Factors associated with quality of life (QOL) in Huntington’s disease (HD). In: 5th Medical Research Symposium 2019, 9th October 2019, IIUM Medical Centre, Kuantan, Pahang. (Unpublished) |
| spellingShingle | RZ Other systems of medicine Md Rosli, Najwa Hanim Mangelsdorf, Simone Farrand, Sarah Loi, Samantha M Eratne, Dhamidhu Velakoulis, Dennis Factors associated with quality of life (QOL) in Huntington’s disease (HD). |
| title | Factors associated with quality of life (QOL) in Huntington’s disease (HD). |
| title_full | Factors associated with quality of life (QOL) in Huntington’s disease (HD). |
| title_fullStr | Factors associated with quality of life (QOL) in Huntington’s disease (HD). |
| title_full_unstemmed | Factors associated with quality of life (QOL) in Huntington’s disease (HD). |
| title_short | Factors associated with quality of life (QOL) in Huntington’s disease (HD). |
| title_sort | factors associated with quality of life (qol) in huntington’s disease (hd). |
| topic | RZ Other systems of medicine |
| url | http://irep.iium.edu.my/75412/ http://irep.iium.edu.my/75412/1/full.pdf |