Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat
Oral candidiasis is the final outcome of the vulnerability of the host as the virulence of the invading organism. A major virulence factor of Candida albicans is its ability to adapt to different environments. The treatment in such cases is challenging. Therefore, the study of experimentally induced...
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| Format: | Proceeding Paper |
| Language: | English English English |
| Published: |
2019
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| Online Access: | http://irep.iium.edu.my/73687/ http://irep.iium.edu.my/73687/1/CCI29072019.jpg http://irep.iium.edu.my/73687/2/CCI29072019.pdf http://irep.iium.edu.my/73687/3/CCI29072019_0001.jpg |
| _version_ | 1848787840498925568 |
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| author | Mustafa Al-Ahmad, Basma Ezzat |
| author_facet | Mustafa Al-Ahmad, Basma Ezzat |
| author_sort | Mustafa Al-Ahmad, Basma Ezzat |
| building | IIUM Repository |
| collection | Online Access |
| description | Oral candidiasis is the final outcome of the vulnerability of the host as the virulence of the invading organism. A major virulence factor of Candida albicans is its ability to adapt to different environments. The treatment in such cases is challenging. Therefore, the study of experimentally induced oral candidiasis in rats is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic designs . When growing on a medical device or mucosal surface, Candida albicance reside as communities embedded in a protective matrix, they resist the host defenses, which include depositing and incorporation of several proteins into the biofilm matrix. This study is describing the host’s response to Candida biofilms , it emphasizes the role of the denture base material in enhancing the colonization, proliferation of candida albicans and the inflammation of the palatal mucosa.
Palatal candidiasis is seen after one week of fitting the dentures on the rat palate, while during the second week alternating epithelial hyperplasia and atrophy occurs, Intra-epithelial polymorphonuclear leukocyte infiltration and chronic inflammatory cell infiltration in the underlying connective tissue was observed . The transmission of candida from blastospore to mycelium occurs after one week and mycelium is predominated at the third week, however hyperorthokeratinization at the fourth week was observed. This constitutes a good evidence for anti candidal protection during oral candidiasis, which will have the potential for including such studies as a powerful tool in understanding the pathogenesis, host interactions, and the management of oral mucosal candidal infections. |
| first_indexed | 2025-11-14T17:31:19Z |
| format | Proceeding Paper |
| id | iium-73687 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:31:19Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-736872019-08-02T04:09:13Z http://irep.iium.edu.my/73687/ Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat Mustafa Al-Ahmad, Basma Ezzat RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works Oral candidiasis is the final outcome of the vulnerability of the host as the virulence of the invading organism. A major virulence factor of Candida albicans is its ability to adapt to different environments. The treatment in such cases is challenging. Therefore, the study of experimentally induced oral candidiasis in rats is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic designs . When growing on a medical device or mucosal surface, Candida albicance reside as communities embedded in a protective matrix, they resist the host defenses, which include depositing and incorporation of several proteins into the biofilm matrix. This study is describing the host’s response to Candida biofilms , it emphasizes the role of the denture base material in enhancing the colonization, proliferation of candida albicans and the inflammation of the palatal mucosa. Palatal candidiasis is seen after one week of fitting the dentures on the rat palate, while during the second week alternating epithelial hyperplasia and atrophy occurs, Intra-epithelial polymorphonuclear leukocyte infiltration and chronic inflammatory cell infiltration in the underlying connective tissue was observed . The transmission of candida from blastospore to mycelium occurs after one week and mycelium is predominated at the third week, however hyperorthokeratinization at the fourth week was observed. This constitutes a good evidence for anti candidal protection during oral candidiasis, which will have the potential for including such studies as a powerful tool in understanding the pathogenesis, host interactions, and the management of oral mucosal candidal infections. 2019-07-22 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/73687/1/CCI29072019.jpg application/pdf en http://irep.iium.edu.my/73687/2/CCI29072019.pdf application/pdf en http://irep.iium.edu.my/73687/3/CCI29072019_0001.jpg Mustafa Al-Ahmad, Basma Ezzat (2019) Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat. In: Annual World of Dental and Oral Health Congress, 22-23 July 2019, Singapore. (Unpublished) |
| spellingShingle | RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works Mustafa Al-Ahmad, Basma Ezzat Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat |
| title | Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat |
| title_full | Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat |
| title_fullStr | Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat |
| title_full_unstemmed | Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat |
| title_short | Histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat |
| title_sort | histopathological and microbiological study of experimentally induced oral candidiasis in wistar rat |
| topic | RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works |
| url | http://irep.iium.edu.my/73687/ http://irep.iium.edu.my/73687/1/CCI29072019.jpg http://irep.iium.edu.my/73687/2/CCI29072019.pdf http://irep.iium.edu.my/73687/3/CCI29072019_0001.jpg |