GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity
ABSTRACT Different extraction processes were employed to extract bioactive metabolites from Salacca zalacca flesh by a range of aqueous and organic solvents. The highest extraction yield was obtained by 50% ethanol extract of SE (73.18 ±4.35%), whereas SFE_1 showed the lowest yield (0.42 ±0.08%). A...
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| Format: | Article |
| Language: | English English |
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Taylor & Francis
2019
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| Online Access: | http://irep.iium.edu.my/70206/ http://irep.iium.edu.my/70206/1/Natural%20Product%20Research%20_2019%20Salak.pdf http://irep.iium.edu.my/70206/7/70206_GC-MS%20analysis%20of%20metabolites%20from%20soxhlet%20extraction%2C%20ultrasound-assisted%20extraction%20and%20supercritical%20fluid%20extraction%20of%20Salacca_scopus.pdf |
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| author | Saleh, Mohammed S M Mohd Bukhari, Dzatil Awanis Siddiqui, Mohammad Jamshed Ahmad Kasmuri, Abdul Razak Murugesu, Suganya Khatib, Alfi |
| author_facet | Saleh, Mohammed S M Mohd Bukhari, Dzatil Awanis Siddiqui, Mohammad Jamshed Ahmad Kasmuri, Abdul Razak Murugesu, Suganya Khatib, Alfi |
| author_sort | Saleh, Mohammed S M |
| building | IIUM Repository |
| collection | Online Access |
| description | ABSTRACT
Different extraction processes were employed to extract bioactive metabolites from Salacca zalacca flesh by a range of aqueous and organic solvents. The highest extraction yield was obtained by 50% ethanol extract of SE (73.18 ±4.35%), whereas SFE_1 showed the lowest yield (0.42 ±0.08%). All extracts were evaluated for in vitro a-glucosidase inhibitory activity, measured by their IC50 values in comparison to that of quercetin, the positive control (IC50 ¼ 2.7 ±0.7 lg/mL). The lowest a-glucosidase inhibitory activity was
indicated by water extract of SE (IC50 ¼ 724.3 ±42.9 lg/mL) and
the highest activity was demonstrated by 60% ethanol extract by
UAE (IC50 ¼ 16.2 ± 2.4 lg/mL). All extracts were analysed by GC-MS and identified metabolites like carbohydrates, fatty acids, organic acids, phenolic acids, sterols and alkane-based compounds etcetera that may possess the potential as a-glucosidase inhibitor and may attribute to the a-glucosidase inhibitory activity. |
| first_indexed | 2025-11-14T17:21:56Z |
| format | Article |
| id | iium-70206 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:21:56Z |
| publishDate | 2019 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-702062019-08-02T03:37:30Z http://irep.iium.edu.my/70206/ GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity Saleh, Mohammed S M Mohd Bukhari, Dzatil Awanis Siddiqui, Mohammad Jamshed Ahmad Kasmuri, Abdul Razak Murugesu, Suganya Khatib, Alfi QD Chemistry ABSTRACT Different extraction processes were employed to extract bioactive metabolites from Salacca zalacca flesh by a range of aqueous and organic solvents. The highest extraction yield was obtained by 50% ethanol extract of SE (73.18 ±4.35%), whereas SFE_1 showed the lowest yield (0.42 ±0.08%). All extracts were evaluated for in vitro a-glucosidase inhibitory activity, measured by their IC50 values in comparison to that of quercetin, the positive control (IC50 ¼ 2.7 ±0.7 lg/mL). The lowest a-glucosidase inhibitory activity was indicated by water extract of SE (IC50 ¼ 724.3 ±42.9 lg/mL) and the highest activity was demonstrated by 60% ethanol extract by UAE (IC50 ¼ 16.2 ± 2.4 lg/mL). All extracts were analysed by GC-MS and identified metabolites like carbohydrates, fatty acids, organic acids, phenolic acids, sterols and alkane-based compounds etcetera that may possess the potential as a-glucosidase inhibitor and may attribute to the a-glucosidase inhibitory activity. Taylor & Francis 2019-01-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/70206/1/Natural%20Product%20Research%20_2019%20Salak.pdf application/pdf en http://irep.iium.edu.my/70206/7/70206_GC-MS%20analysis%20of%20metabolites%20from%20soxhlet%20extraction%2C%20ultrasound-assisted%20extraction%20and%20supercritical%20fluid%20extraction%20of%20Salacca_scopus.pdf Saleh, Mohammed S M and Mohd Bukhari, Dzatil Awanis and Siddiqui, Mohammad Jamshed Ahmad and Kasmuri, Abdul Razak and Murugesu, Suganya and Khatib, Alfi (2019) GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity. Natural Product Research. ISSN 1478-6419 E-ISSN 1478-6427 (In Press) https://www.tandfonline.com/loi/gnpl20 10.1080/14786419.2018.1560295 |
| spellingShingle | QD Chemistry Saleh, Mohammed S M Mohd Bukhari, Dzatil Awanis Siddiqui, Mohammad Jamshed Ahmad Kasmuri, Abdul Razak Murugesu, Suganya Khatib, Alfi GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity |
| title | GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity |
| title_full | GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity |
| title_fullStr | GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity |
| title_full_unstemmed | GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity |
| title_short | GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity |
| title_sort | gc-ms analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of salacca zalacca flesh and its alpha-glucosidase inhibitory activity |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/70206/ http://irep.iium.edu.my/70206/ http://irep.iium.edu.my/70206/ http://irep.iium.edu.my/70206/1/Natural%20Product%20Research%20_2019%20Salak.pdf http://irep.iium.edu.my/70206/7/70206_GC-MS%20analysis%20of%20metabolites%20from%20soxhlet%20extraction%2C%20ultrasound-assisted%20extraction%20and%20supercritical%20fluid%20extraction%20of%20Salacca_scopus.pdf |