Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size

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Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size

Sclerostin has emerged as an important regulator of bone mass. We have shown that sclerostin can act by targeting late osteoblasts/osteocytes to inhibit bone mineralization and to upregulate osteocyte expression of catabolic factors, resulting in osteocytic osteolysis. Here we sought to examine the...

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Bibliographic Details
Main Authors:	Kogawa, M, Khalid, Kamarul Ariffin, Wijenayaka, Asiri R, Ormsby, Renee T, Evdokiou, A, Anderson, Peter H, Findlay, David M, Atkins, Gerald J
Format:	Article
Language:	English English
Published:	2018
Subjects:	QH301 Biology QP Physiology RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/69488/ http://irep.iium.edu.my/69488/1/ajpcell.00175.2017.pdf http://irep.iium.edu.my/69488/7/Scopus%20-%20Document%20details.pdf

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