Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)
Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components namely : Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D...
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| Format: | Proceeding Paper |
| Language: | English English |
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2018
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| Online Access: | http://irep.iium.edu.my/65455/ http://irep.iium.edu.my/65455/1/CKD%20MBD%20ZENITH.pdf http://irep.iium.edu.my/65455/2/6FB5B9F3-B804-4107-9F6A-202474133357.jpeg |
| _version_ | 1848786392889425920 |
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| author | Wan Ali, Wan Ahmad Syahril Rozli |
| author_facet | Wan Ali, Wan Ahmad Syahril Rozli |
| author_sort | Wan Ali, Wan Ahmad Syahril Rozli |
| building | IIUM Repository |
| collection | Online Access |
| description | Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components namely : Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D metabolism; Abnormalities in bone turnover, mineralization, volume linear growth, or strength; and Extraskeletal calcification.
This topic reviews the pathogenesis of CKD-MBD.
The pathophysiology of the disorder is complex and involves a number of feedback loops between the kidney, bone, intestine, and the vasculature. The main goal of this system is maintenance of calcium and phosphorus balance, often at the expense of abnormalities in other components of the system.
While most elements of CKD–MBD are usually present when the glomerular filtration rate (GFR) falls below 40 mL/min, some components may be observed earlier in the course of CKD and precede the onset of clinically detectable abnormalities in serum phosphorus, calcium, PTH, and vitamin D. These include decreased bone formation rates, vascular calcification, loss of klotho, and increased FGF23 secretion. |
| first_indexed | 2025-11-14T17:08:19Z |
| format | Proceeding Paper |
| id | iium-65455 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:08:19Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-654552018-09-06T06:58:30Z http://irep.iium.edu.my/65455/ Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) Wan Ali, Wan Ahmad Syahril Rozli R Medicine (General) Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components namely : Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D metabolism; Abnormalities in bone turnover, mineralization, volume linear growth, or strength; and Extraskeletal calcification. This topic reviews the pathogenesis of CKD-MBD. The pathophysiology of the disorder is complex and involves a number of feedback loops between the kidney, bone, intestine, and the vasculature. The main goal of this system is maintenance of calcium and phosphorus balance, often at the expense of abnormalities in other components of the system. While most elements of CKD–MBD are usually present when the glomerular filtration rate (GFR) falls below 40 mL/min, some components may be observed earlier in the course of CKD and precede the onset of clinically detectable abnormalities in serum phosphorus, calcium, PTH, and vitamin D. These include decreased bone formation rates, vascular calcification, loss of klotho, and increased FGF23 secretion. 2018-07-15 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/65455/1/CKD%20MBD%20ZENITH.pdf application/pdf en http://irep.iium.edu.my/65455/2/6FB5B9F3-B804-4107-9F6A-202474133357.jpeg Wan Ali, Wan Ahmad Syahril Rozli (2018) Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD). In: Kuantan CKD-MBD Workshop 2018, 15th July 2018, The Zenith Hotel Kuantan. (Unpublished) |
| spellingShingle | R Medicine (General) Wan Ali, Wan Ahmad Syahril Rozli Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) |
| title | Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) |
| title_full | Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) |
| title_fullStr | Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) |
| title_full_unstemmed | Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) |
| title_short | Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) |
| title_sort | understanding chronic kidney disease- mineral bone disorder (ckd-mbd) |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/65455/ http://irep.iium.edu.my/65455/1/CKD%20MBD%20ZENITH.pdf http://irep.iium.edu.my/65455/2/6FB5B9F3-B804-4107-9F6A-202474133357.jpeg |