Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential a...
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| Format: | Article |
| Language: | English English |
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International Islamic University Malaysia
2017
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| Online Access: | http://irep.iium.edu.my/60896/ http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf |
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| author | Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita |
| author_facet | Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita |
| author_sort | Ridzuan, P. M. |
| building | IIUM Repository |
| collection | Online Access |
| description | Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential and its mechanism of action has not been studied yet. The objective of this preliminary study to determine the antifungal properties of HC against T. rubrum using transmission electron microscope (TEM) on gross and ultrastructure of T. rubrum hypha. T. rubrum was treated with HC and miconazole (MI) at concentrations of 1.25, 2.5, 5 and 10 mg/mL for 1, 3, 5 and 7 days continuously. Generally, fungi structures became more severely damaged at increasing treatment duration. Microscopically, the fungi’s cell wall treated with HC showed a rough surface, shrinkage and demolition similar to the MI treated group. The fungi organelles were also demolished and disorganized. This study revealed that HC has the ability to inhibit T. rubrum growth and has potential to be an antifungal agent for skin infections. |
| first_indexed | 2025-11-14T16:55:16Z |
| format | Article |
| id | iium-60896 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:55:16Z |
| publishDate | 2017 |
| publisher | International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-608962018-01-12T11:24:05Z http://irep.iium.edu.my/60896/ Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita QR Microbiology Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential and its mechanism of action has not been studied yet. The objective of this preliminary study to determine the antifungal properties of HC against T. rubrum using transmission electron microscope (TEM) on gross and ultrastructure of T. rubrum hypha. T. rubrum was treated with HC and miconazole (MI) at concentrations of 1.25, 2.5, 5 and 10 mg/mL for 1, 3, 5 and 7 days continuously. Generally, fungi structures became more severely damaged at increasing treatment duration. Microscopically, the fungi’s cell wall treated with HC showed a rough surface, shrinkage and demolition similar to the MI treated group. The fungi organelles were also demolished and disorganized. This study revealed that HC has the ability to inhibit T. rubrum growth and has potential to be an antifungal agent for skin infections. International Islamic University Malaysia 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf application/pdf en http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf Ridzuan, P. M. and Mohamad, Nasir and Ismail, Salwani and A. Rahman, Nor Iza and Sanusi, N. A. and Umar, Rabiatul Adawiyah and Hamzah, Hairul Aini and Buyong, Zunariah and Mohd Hassan, Norazian and Baharudin, Roesnita (2017) Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol. International Medical Journal Malaysia, 16 (2). pp. 65-71. ISSN 1823-4631 E-ISSN 1823-4631 |
| spellingShingle | QR Microbiology Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol |
| title | Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol |
| title_full | Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol |
| title_fullStr | Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol |
| title_full_unstemmed | Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol |
| title_short | Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol |
| title_sort | ultra-morphological changes of trichophyton rubrum treated with hydroxychavicol |
| topic | QR Microbiology |
| url | http://irep.iium.edu.my/60896/ http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf |