Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
Natural products have traditionally been used for medicinal purposes in Asian communities. Toxicity studies typically use animal testing to predict the harmfulness of a particular substance to human health. For this study, in lieu of animal testing, we utilized cell-based biosensors to evaluate the...
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| Format: | Article |
| Language: | English |
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UTM Press
2017
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| Online Access: | http://irep.iium.edu.my/60579/ http://irep.iium.edu.my/60579/1/841-3332-1-PB.pdf |
| _version_ | 1848785515215585280 |
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| author | Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin |
| author_facet | Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin |
| author_sort | Mohd Mansor, Ahmad Fairuzabadi |
| building | IIUM Repository |
| collection | Online Access |
| description | Natural products have traditionally been used for medicinal purposes in Asian communities. Toxicity studies typically use animal testing to predict the harmfulness of a particular substance to human health. For this study, in lieu of animal testing, we utilized cell-based biosensors to evaluate the toxicity of natural products. The cell-based biosensors were fabricated on a printed circuit board with copper electrodes and equipped with PDMS cell culture chambers. Two different electrodes (interdigitated and circular) were designed. Vero cells were used to represent normal healthy cells. The cells were first cultured on the biosensors and then inoculated with natural products, Taxol (chemo drug – positive control), and DMSO (negative control). Impedances of these biosensors were afterwards recorded at six-hour intervals for 80 hours to determine the growth of the cells. It was found that as compared to Taxol, natural products have substantially low toxicant values. |
| first_indexed | 2025-11-14T16:54:22Z |
| format | Article |
| id | iium-60579 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:54:22Z |
| publishDate | 2017 |
| publisher | UTM Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-605792018-01-11T02:38:18Z http://irep.iium.edu.my/60579/ Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices Natural products have traditionally been used for medicinal purposes in Asian communities. Toxicity studies typically use animal testing to predict the harmfulness of a particular substance to human health. For this study, in lieu of animal testing, we utilized cell-based biosensors to evaluate the toxicity of natural products. The cell-based biosensors were fabricated on a printed circuit board with copper electrodes and equipped with PDMS cell culture chambers. Two different electrodes (interdigitated and circular) were designed. Vero cells were used to represent normal healthy cells. The cells were first cultured on the biosensors and then inoculated with natural products, Taxol (chemo drug – positive control), and DMSO (negative control). Impedances of these biosensors were afterwards recorded at six-hour intervals for 80 hours to determine the growth of the cells. It was found that as compared to Taxol, natural products have substantially low toxicant values. UTM Press 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60579/1/841-3332-1-PB.pdf Mohd Mansor, Ahmad Fairuzabadi and Abbas, Phirdaous and Hamdan, Taufik Hakim and Hashim, Yumi Zuhanis Has-Yun and Nordin, Anis Nurashikin (2017) Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor. Malaysian Journal of Fundamental and Applied Sciences. pp. 540-545. ISSN 2289-5981 E-ISSN 2289-599X |
| spellingShingle | TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor |
| title | Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor |
| title_full | Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor |
| title_fullStr | Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor |
| title_full_unstemmed | Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor |
| title_short | Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor |
| title_sort | toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor |
| topic | TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices |
| url | http://irep.iium.edu.my/60579/ http://irep.iium.edu.my/60579/1/841-3332-1-PB.pdf |