Early result: randomized controlled trial of treatment for intermittent claudication
Objective: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoro-popliteal disease Methods: Over a 6 years period, 178 patients (108 men, median age 70 years) with angioplastiable femoro-popliteal lesions were rando...
| Main Authors: | , , , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English |
| Published: |
Wiley
2008
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/59154/ http://irep.iium.edu.my/59154/1/British%20Journal%20of%20Surgery%202008%2C%2095%28S6%29%2C%201%E2%80%93104.pdf |
| _version_ | 1848785253435441152 |
|---|---|
| author | Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter |
| author_facet | Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter |
| author_sort | Khan, Mazari Fayyaz Ali |
| building | IIUM Repository |
| collection | Online Access |
| description | Objective: To compare angioplasty (PTA), supervised exercise (SEP) and PTA
+ SEP in the treatment of intermittent claudication (IC) due to femoro-popliteal
disease
Methods: Over a 6 years period, 178 patients (108 men, median age 70 years)
with angioplastiable femoro-popliteal lesions were randomized to: PTA, SEP or
PTA + SEP. Patients were assessed prior to and at 1 & 3 month post treatment.
ISCVS outcome criteria (Ankle pressures, treadmill walking distances) and
Quality of Life (QoL) questionnaires (SF36 and VascuQoL) were analysed.
Results: All groups were well matched at baseline. 21 patients withdrew.
Intra group analysis: All groups demonstrated significant clinical and QoL
improvements (Friedman test, p < 0·05). SEP (59 patients, 8 withdrew) – 62·7%
of patients (n = 32) improved following treatment [20 mild, 9 moderate, 3
marked], 27·4% (n = 14) no improvement and 9·8% (n = 5) deteriorated. PTA
(60 patients, 3 withdrew) – 66·6% of patients (n = 38) improved following
treatment [19mild, 10 moderate, 9 marked], 22·8% (n = 13) no improvement
and 10·5% (n = 6) deteriorated. PTA + SEP (59 patients, 10 withdrew) – 81·6%
of patients (n = 40) improved following treatment. [10 mild, 17 moderate, 13
marked], 14·2%% (n = 7) no improvement and 4·0% (n = 2) deteriorated Inter
group Analysis: PTA + SEP produce a much greater improvement in clinical
outcome measures than PTA or SEP alone, but there was no significant Q0L
advantage (Kruskal Wallis test, p > 0·05).
Conclusion: SEP should be the primary treatment for the patients with
claudication and PTA should be supplemented by a SEP. |
| first_indexed | 2025-11-14T16:50:12Z |
| format | Proceeding Paper |
| id | iium-59154 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:50:12Z |
| publishDate | 2008 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-591542017-11-07T08:36:39Z http://irep.iium.edu.my/59154/ Early result: randomized controlled trial of treatment for intermittent claudication Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter RD Surgery Objective: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoro-popliteal disease Methods: Over a 6 years period, 178 patients (108 men, median age 70 years) with angioplastiable femoro-popliteal lesions were randomized to: PTA, SEP or PTA + SEP. Patients were assessed prior to and at 1 & 3 month post treatment. ISCVS outcome criteria (Ankle pressures, treadmill walking distances) and Quality of Life (QoL) questionnaires (SF36 and VascuQoL) were analysed. Results: All groups were well matched at baseline. 21 patients withdrew. Intra group analysis: All groups demonstrated significant clinical and QoL improvements (Friedman test, p < 0·05). SEP (59 patients, 8 withdrew) – 62·7% of patients (n = 32) improved following treatment [20 mild, 9 moderate, 3 marked], 27·4% (n = 14) no improvement and 9·8% (n = 5) deteriorated. PTA (60 patients, 3 withdrew) – 66·6% of patients (n = 38) improved following treatment [19mild, 10 moderate, 9 marked], 22·8% (n = 13) no improvement and 10·5% (n = 6) deteriorated. PTA + SEP (59 patients, 10 withdrew) – 81·6% of patients (n = 40) improved following treatment. [10 mild, 17 moderate, 13 marked], 14·2%% (n = 7) no improvement and 4·0% (n = 2) deteriorated Inter group Analysis: PTA + SEP produce a much greater improvement in clinical outcome measures than PTA or SEP alone, but there was no significant Q0L advantage (Kruskal Wallis test, p > 0·05). Conclusion: SEP should be the primary treatment for the patients with claudication and PTA should be supplemented by a SEP. Wiley 2008 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/59154/1/British%20Journal%20of%20Surgery%202008%2C%2095%28S6%29%2C%201%E2%80%93104.pdf Khan, Mazari Fayyaz Ali and Sumit, Gulati and Lee, H. L. D. and Tapan, Mehta and Abdul Rahman, Mohd Norhisham Azmi and Ian, Chetter (2008) Early result: randomized controlled trial of treatment for intermittent claudication. In: 43rd Congress of the European Society for Surgical Research 2008, 21st-24th May 2008, Warsaw, Poland. https://www.bjs.co.uk/ |
| spellingShingle | RD Surgery Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter Early result: randomized controlled trial of treatment for intermittent claudication |
| title | Early result: randomized controlled trial of treatment for intermittent claudication |
| title_full | Early result: randomized controlled trial of treatment for intermittent claudication |
| title_fullStr | Early result: randomized controlled trial of treatment for intermittent claudication |
| title_full_unstemmed | Early result: randomized controlled trial of treatment for intermittent claudication |
| title_short | Early result: randomized controlled trial of treatment for intermittent claudication |
| title_sort | early result: randomized controlled trial of treatment for intermittent claudication |
| topic | RD Surgery |
| url | http://irep.iium.edu.my/59154/ http://irep.iium.edu.my/59154/ http://irep.iium.edu.my/59154/1/British%20Journal%20of%20Surgery%202008%2C%2095%28S6%29%2C%201%E2%80%93104.pdf |