Dynamics of the oncofetal ecosystem during Hepatocellular carcinoma evolution
This study uses single-cell RNA sequencing to analyse early- and late-stage hepatocellular carcinoma (HCC) patient samples, revealing an enrichment of oncofetal populations and exhausted CD8+ T cells in late-stage HCC. Cell-cell interaction analyses identified VEGFA signalling by hepatocytes and CXC...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/98119 |
| _version_ | 1848766365102505984 |
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| author | Pai, Rhea Girish |
| author_facet | Pai, Rhea Girish |
| author_sort | Pai, Rhea Girish |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This study uses single-cell RNA sequencing to analyse early- and late-stage hepatocellular carcinoma (HCC) patient samples, revealing an enrichment of oncofetal populations and exhausted CD8+ T cells in late-stage HCC. Cell-cell interaction analyses identified VEGFA signalling by hepatocytes and CXCL12-CXCR4 signalling by oncofetal populations as key drivers of tumour progression. These interactions may initiate oncofetal reprogramming in the tumour microenvironment, with findings validated by spatial assay, highlighting potential therapeutic targets in advanced HCC. |
| first_indexed | 2025-11-14T11:49:59Z |
| format | Thesis |
| id | curtin-20.500.11937-98119 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:49:59Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-981192025-07-18T06:18:56Z Dynamics of the oncofetal ecosystem during Hepatocellular carcinoma evolution Pai, Rhea Girish This study uses single-cell RNA sequencing to analyse early- and late-stage hepatocellular carcinoma (HCC) patient samples, revealing an enrichment of oncofetal populations and exhausted CD8+ T cells in late-stage HCC. Cell-cell interaction analyses identified VEGFA signalling by hepatocytes and CXCL12-CXCR4 signalling by oncofetal populations as key drivers of tumour progression. These interactions may initiate oncofetal reprogramming in the tumour microenvironment, with findings validated by spatial assay, highlighting potential therapeutic targets in advanced HCC. 2024 Thesis http://hdl.handle.net/20.500.11937/98119 Curtin University restricted |
| spellingShingle | Pai, Rhea Girish Dynamics of the oncofetal ecosystem during Hepatocellular carcinoma evolution |
| title | Dynamics of the oncofetal ecosystem during
Hepatocellular carcinoma evolution |
| title_full | Dynamics of the oncofetal ecosystem during
Hepatocellular carcinoma evolution |
| title_fullStr | Dynamics of the oncofetal ecosystem during
Hepatocellular carcinoma evolution |
| title_full_unstemmed | Dynamics of the oncofetal ecosystem during
Hepatocellular carcinoma evolution |
| title_short | Dynamics of the oncofetal ecosystem during
Hepatocellular carcinoma evolution |
| title_sort | dynamics of the oncofetal ecosystem during
hepatocellular carcinoma evolution |
| url | http://hdl.handle.net/20.500.11937/98119 |