Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality

Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively...

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Main Authors: Adewuyi, Emmanuel, Mehta, D., Sapkota, Y., Yoshihara, K., Nyegaard, M., Steinthorsdottir, V., Morris, A.P., Fassbender, A., Rahmioglu, N., Vivo, I.D., Buring, J.E., Zhang, F., Edwards, T.L., Jones, S., Dorien, Peterse, D., Rexrode, K.M., Ridker, P.M., Schork, A.J., MacGregor, S., Martin, N.G., Becker, C.M., Adachi, S., Enomoto, T., Takahashi, A., Kamatani, Y., Matsuda, K., Kubo, M., Thorleifsson, G., Geirsson, R.T., Thorsteinsdottir, U., Wallace, L.M., Yang, J., Velez Edwards, D.R., Low, S.K., Zondervan, K.T., Missmer, S.A., D’Hooghe, T., Stefansson, K., Tung, J.Y., Montgomery, G.W., Chasman, D.I., Nyholt, D.R., Agee, M., Alipanahi, B., Auton, A., Bell, R.K., Bryc, K., Elson, S.L., Fontanillas, P., Furlotte, N.A., Huber, K.E., Kleinman, A., Litterman, N.K., McIntyre, M.H., Mountain, J.L., Noblin, E.S., Northover, C.A.M., Pitts, S.J., Sathirapongsasuti, J.F., Sazonova, O.V., Auta, A., Wilson, C.H., Griffiths, L.R.
Format: Journal Article
Language:English
Published: 2021
Subjects:
Depression
Endometriosis
Female
Gastric Mucosa
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
International Endogene Consortium
23andMe Research Team
Online Access:http://hdl.handle.net/20.500.11937/97788

Internet

http://hdl.handle.net/20.500.11937/97788

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